Effect of different blood pressure levels on cerebral vascular haemodynamics among young and middle-aged healthy males

ZHANG Shasha; CHEN Xuetao; WANG Haiyin; LIANG Xiaoyu; HUANG Cuiying; WEN Teng; WANG Xinyan

Abstract：Objective To investigate the relationships between blood pressure levels and cerebral vascular haemodynamicsamong young and middle-aged healthy males and the effect of high levels of normal blood pressure on cerebral vascular haemodynamics.Methods 182 young and middle-aged healthy men aged 23 to 46 years (average 28.73±5.47 years) were enrolled in this study. A-PULSE CASPro Central Aortic Systolic Pressure Monitoring Device was used to measure the brachial systolic pressure (SBP), diastolic pressure (DBP), mean arterial pressure (MAP), pulse rate (PR), amd central aortic systolic pressure (CASP). The average blood flow rate(Vm), peak systolic blood flow velocity (Vs), end-diastolic blood flow velocity (Vd), pulsatility index (PI) and resistance index (RI) of middle cerebral artery (MCA), internal carotid artery(ICA), anterior cerebral artery (ACA), posterior cerebral artery (PCA), vertebral artery (VA) and basal artery (BA) were detected by transcranial Doppler sonography (TCD).Results ①The brachial systolic pressure (SBP), brachial diastolic pressure (DBP) and central aortic systolic pressure (CASP) of high normal group were significantly higher than those of normal blood pressure group (P<0.01).②There were no obvious correlations between cerebral vascular blood flow velocity, pulsatility indexes, resistance indexes and brachial systolic pressure, central aortic systolic pressure in young and middle-aged healthy males (P>0.05).③The difference of indexes of cerebral vascular haemodynamics among young and middle-aged healthy men was of no statistic significance between high normal group and normal blood pressure group (P>0.05) .Conclusion There were no linear correlations between blood pressure and indexes of cerebral vascular hemodynamics among young and middle-aged healthy males with brachial systolic pressure below 140 mmHg. Compared with normal blood pressure group, high normal blood pressure does not lead to large fluctuations in indexes of cerebral vascular haemodynamics.