Application of salmon calcitonin in elder patient's total hip arthroplasty

HU Caijie

Abstract：ObjectiveTo observe the effect of salmon calcitonin on bone metabolism, joint function recovery and life quality of elder patients after total hip anthroplasty and evaluate the clinical value.Methods134 patients above sixty who underwent total hip arthroplasty were divided into observation group (67 cases) and control group (67 cases) in Shenyang Osteological Hospital. Salmon calcitonin was given to observation group, followed by a follow-up of six months. Serum osteocalcin (OC), C-terminal telopeptides of typeⅠ collagen (β-CTX), bone alkaline phosphatase (BALP), Ca2+, bone mineral density (BMD), pain intensity differences (PID), joint function and life quality scores were detected.ResultsThe level of serum OC in observation group was higher than in control group 1, 3 and 6 month post-operatively(P<0.05) while the level of serumβ-CTX in observation group was lower than in control group 3 and 6 months post-operatively(P<0.05). The level of serum BALP in observation group was lower than in control group 1, 3, and 6 months post-operatively(P<0.05). The level of serum Ca2+ in observation group was higher than in control group 3 and 6 months post-operatively(P<0.05). BMD in observation group was higher than in control group 1, 3 and 6 months post-operatively(P<0.05). The long-term pain PID score in observation group was higher than in control group(P<0.05). Straight leg-raising 30° time in observation group was shorter than in control group(P<0.05). Hip adducting 45° in observation group was shorter than in control group (P<0.01). Harris score in observation group was higher than in control group(P<0.05). SF-36 scores in observation group were higher than in control group(P<0.05).ConclusionSalmon calcitonin can promote ossification, inhibit osteolysis, relieve long-term pain, facilitate joint function recovery and improve life quality in elder patients after total hip arthroplasty.