Expression of BTG1 protein in gastric cancer and its clinical significance

WANG Qinyi; ZHANG Xu

Abstract：Objective To investigate the expression level of BTG1 protein in gastric tumor tissues and its clinical significance. Methods Fifty-four patients of gastric cancer who had undergone radical gastrectomy in our hospital were randomly selected between June 2013 and December 2015 as observation group, with 48 healthy subjects in our hospital as control. BTG1 mRNA levels of both groups were analyzed by real-time fluorescent quantitative PCR while BTG1 protein was analyzed using the immunohistochemical method. According to the BTG1 expression level, patients in observation group were divided into positive group and negative group before the correlations between the patients' BTG1 expression level and their clinical pathological features were analyzed. Results Compared with control group, BTG1 mRNA level in observation group was significantly reduced (P<0.05). Compared with control group, BTG1 protein in tumor tissues was significantly reduced, and the difference was statistically significant (P<0.05). There was a negative correlation between BTG1 protein expression level and gastric cancer tissue classification, clinical stage, tumor infiltration and lymph node metastasis (P<0.05). Conclusion BTG1 protein has a lower expression in gastric cancer. It is closely related to BTG1 protein expression level, gastric cancer tissue classification, clinical stage, tumor infiltration and lymph node metastasis. BTG1 can be used as an auxiliary index of clinical prognosis.