Study of relationship of positive acceleration tolerance and plasma C-reactive protein and endothelin-1 levels in swines with different coronary artery stenosis
YUE Ran
LIU Xingde
ZHANG Haitao
ZHANG Chao
LUO Huilan
CHEN Yongsheng
Abstract：Objective To study the relationships between positive acceleration (+Gz) tolerance and the changes of plasma C-reactive protein (CRP) and endothelin-1 (ET-1) levels in swines with different coronary artery stenosis. Methods Fifteen of the twenty Bama miniature swines were randomly assigned to three observation groups using silk suture under direct vision of the thoracoscope to establish different coronary artery stenosis models: mild, moderate and severe. Another 5 swines underwent a sham operation as control group. The relationships between positive acceleration (+Gz) tolerance and plasma C-reactive protein and endothelin-1 levels in swines were observed under exposure to +Gz stress (<9 Gz) in the centrifuge model. Results Compared to mild stenosis group and sham-operation group, the maximal tolerated +Gz values in moderate stenosis group and severe stenosis group were decreased significantly under +Gz exposure(P<0.05). Compared to the sham-operation group, the levels of plasma CRP and ET-1 were significantly increased in moderate stenosis group and severe stenosis group (P<0.05). There were no significant changes of plasma CRP and ET-1 in mild stenosis group. A significant correlation between plasma CRP and ET-1 was observed under +Gz exposure(r=0.894,P<0.01). Conclusion The greater stenosis becomes, a greater degradation of positive acceleration (+Gz) tolerance is observed. Meanwhile, the level of plasma CRP and ET-1 can increase synchronously under +Gz exposure.
Keywords：Miniature swineAccelerationCoronary stenosisC-reactive proteinEndothelin-1
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 154-156 )