The clinical relevance of MMP-14 and EMMPRIN expressing in oral squamous cell carcinoma

WANG Xiaolong; JIA Yulin; SHU Chuanji

Abstract：ObjectiveTo discuss the clinical relevance of MMP-14 and EMMPRIN expressing in oral squamous cell carcinoma(OSCC).MethodSixty-nine cases of patients with OSCC were chosen from January 2012 to June 2014 in our hospital and were divided into the OSCC group. At the same time, 43 cases patients with normal oral tissues were chosen as the control group. The expression levels of MMP-14 and EMMPRIN mRNA were detected by using RT-PCR.Result The expression of MMP-14 and EMMPRIN mRNA in OSCC group was significantly higher than that of the control group (t=8.198, 9.624,P<0.01). Concerning OSCC, there were no statistical differences in the expression of EMMPRIN and MMP-14 mRNA in age and gender (P>0.05), but they increased significantly when in lymph node metastasis,Ⅲ~Ⅳ stage and moderate or poor differentiation (t=3.376, 2.667, 3.027, 2.399,P<0.05); the correlation coefficient between the expression of mRNA MMP-14 and EMMPRIN was 0.821, which indicated positive correlation (P<0.01).ConclusionThe expression levels of MMP-14 and EMMPRIN mRNA in the OSCC have a close relationship with pathological stage, differentiation and lymph node metastasis, which shows the MMP-14 and EMMPRIN are involved in the invasion and metastasis of OSCC. It can be helpful to estimate the severity and the prognosis of the OSCC by detecting the expression of MMP-14 and EMMPRIN mRNA.