Expressions and clinical signiifcance of S100A3 in gastric cancer
LIU Ji
LI Xue
LI Jipeng
WANG Weizhong
Abstract：ObjectiveTo explore the expression and clinical significance of S100A3 within gastric cancer. MethodsCombined with analysis of RT-PCR, Western blot and Tissue microarray(TMA), the mRNA and protein expression levels of S100A3 in normal and malignant stomach tissues and cell lines were systematically investigated. ResultsThe mean expression levels of S100A3 in gastric cancer tissues were 2.5 times as high as in adjacent non-tumorous tissues. S100A3 expression was correlated with tumor differentiation and TNM stage of gastric cancer. S100A3 was overexpression in gastric cancer cell lines. The mean expression levels of S100A3 protein in gastri cancer were higher. ConclusionOverexpressed S100A3 may be associated with the differentiation and progression of gastric cancer.
Keywords：Gastric cancer/pathologyS100A3Tumor differentiationTumor node metastasis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 91-93 )