Clinical study of combining pancreatic kininogenase powder-injection united mecobalamin injection treatment for diabetic peripheral neuropathy
XIAOLi
GUAN Xiaohong
WU Shibai
Abstract：Objective To investigate the clinical efficacy of combining pancreatic kininogenase powder-injection with mecobalamin injection to treat diabetic peripheral neuropathological progress.Methods 80 patients clinically diagnosed diabetic peripheral neuropathy were randomly divided into treatment and control groups. Both groups were only given hypoglycemic, lipid-lowering and other conventional treatments. The control group was given mecobalamin injection, and the treatment group was given mecobalamin injection combined with pancreatic kininogenase powder-injection. They were both treated for 4 weeks. The changes of patients' clinical symptom scores and EMG indexes were evaluated before and after the treatment.Results The overall effective rate of the treatment group was 85%, which was significantly higher than the control group(70%,P<0.05). Neuropathy symptom score and the motor nerve conduction velocity of each subject's nerve were more significantly improved in the treatment group than the control group(P<0.05). During the treatment process, and there was 1 case of gastrointestinal discomfort in control group, and there was no significant adverse reaction in other cases, or no liver and kidney dysfunction.Conclusion Pancreatic kininogenase powder-injection joint with mecobalamine injection in the treatment of diabetic peripheral neuropathy is safe and more effective than the mecobalamin injection alone.
Keywords：Diabetic peripheral neuropathyPancreatic kininogenaseMicrocirculation
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 255-257 )