The signiifcance of analysis of blood drug concentration of valproate for the application of pediatric epilepsy on poisoning reaction
ZHAO Wencui
ZHANG Qi
Abstract：Objective To investigate the significance of analysis of blood drug concentration of valproate for the application of pediatric epilepsy on poisoning reaction.Methods 244 children with epilepsy were given sodium valproate treatment to detect the drug concentration in serum, with application of fluorescence polarization immunoassay, recording the treatment effective rate and the toxic reaction rate of each patient.Results After sodium valproate treatment, the poisoning reaction rate(16.7%)of drug concentration of>100 mg/L group was higher than that of 50~100 mg/L group(2.4%)and≤50 mg/L group(1.0%)(P<0.05); the poisoning reaction rate(9.4%)of≤6 years old patients was higher than that of the 6~9 years old group(3.8%)and>9 years old group(2.7%)but with no statistical significance(P>0.05).Conclusion The poisoning reaction rate was closely related to the blood concentration, monitoring the serum concentration of sodium valproate has an important significance for preventing poisoning reaction.
Keywords：Blood drug concentrationPediatric epilepsySodium valproateToxic reaction
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 233-234,239 )