Effects of modified ultrafiltration on low weight adults undergoing cardiac surgery with cardiopulmonary bypass

CHENG Ji; LI Jingjing; ZHANG Sixin; ZHANG Junwei; LI Zhanjian

Abstract：ObjectiveTo observe the effects of modified ultrafiltration (MUF) on low-weight adults undergoing cardiac surgeries with cardiopulmonary bypass (CPB).Methods36 low-weight (<45 kg) adult patients undergoing open-heart procedure were randomized to the conventional CPB group (control group,n=18) and modified ultrafiltration group(MUF group,n=18). The following indices were analyzed: transfused blood volume during and after the operation, postoperative chest drainage, hematocrit levels before operation, during bypass, terminal of bypass and 24 hours postoperative. Also the hemodynamics, alveolar-arterial oxygen gradient (AaDO2), time to extubation and ICU-stay were observed.ResultsThe patients in MUF group had a greater rise in hematocrit [(22.8±2.4)%vs (27.9±1.8)%,P=0.027], reduce in postoperative bleeding[(447±79) mlvs (203±71) ml, P=0.012] and transfusion requirement[RBC (2.4±1.1)Uvs(1.0±0.2)U,P=0.008]. The MAP [(70±4.2) mmHgvs (81.8±9.1) mmHg,P=0.027] increased, the AaDO2 was better in MUF group (P<0.05), the dosage of inotropic drugs were significant different between two groups (P>0.05) . The time to intubation and ICU-stay was shorter in MUF group than that in control group (P<0.05).ConclusionThis study demonstrates that MUF can filtrate extra fluid directly to concentrate blood after CPB in low weight patients, reduce the blood loss effectively and blood transfusion requirements after cardiac surgery, and improve the hemodynamic and lung function.