Inhibition and SAHA combined with DDP on cervical cancer xenografts in nude mice
TIAN Zhihua
HAO GangHua
HOU Xiaojing
XING Jun
Abstract：[Absrract]ObjectiveTo study the effect of histone deacetylase inhibitor SAHA (N-Hydroxy-N-phenyloctanediamide) combined with cis-diamminedichloroplatinum (DDP) on cervical cancer cells (SiHa) in nude mice.MethodsCervical cancer cell suspension was subcutaneously injected into 40 nude mice to establish cervical cancer model. When the transplanted tumor was about 8 mm in length, 36 mice with tumor in similar size were selected and divided into six groups (control group, 25 mg/kg SAHA group, 50 mg/kg SAHA group, 5 mg/kg DDP group, 25 mg/kg SAHA+DDP group) , and 50 mg/kg SAHA+DDP group. Nude mice were killed on the 17th day. Wet weight of tumor, inhibitory rate and tumor volume were collected. SPSS 19.0 software was used for statistical analysis.ResultsCompared with the control group, the DDP plus SAHA group showed superiority in inhibiting tumor growth (P<0.05).ConclusionThe effects from SAHA and DDP might be associated with down-regulating expressions of HDAC1 protein.
Keywords：SiHaNude miceSAHADDPHDAC1Inhibion effect
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 158-161 )