Expression of Prox-1 in colorectal carcinoma and its relationship with lymphatic vessel density
XIAO Shiyao
YANG Wenbin
YANG Heng
Abstract：ObjectiveTo explore the expression of the transcription factor Prox-1 in colorectal carcinoma and its relationship with lymphatic vessel density, and clinical significance.MethodsFifty colorectal carcinoma patients were included in this study. RT-PCR was used to detect the expression of Prox-1in paracarcinoma tissues and normal colorectal tissues; immunohistochemical method (SP) was used to examine the lymphatic vessel density(LVD).ResultsThe expression of Prox-1 mRNA in paracarcinoma tissues was significantly higher than that in normal tissues (t=6.232,P<0.05) ; the LVD in paracarcinoma tissues was significantly higher than that in normal tissues(t=8.627,P<0.05). The expression of Prox-1 mRNA in paracarcinoma tissues had positively linear relation with LVD(r=0.621,P<0.05). The expression of Prox-1 of paracarcinoma tissues in dimension of invasion depth (t=3.310,P<0.05),TNM staging(t=3.341,P<0.05) and lymph node metastasis(t=2.689,P<0.05) showed significant difference.ConclusionThe overexpression of Prox-1 in paracarcinoma tissue is related to lymphatic metastasis, depth of invasion and TNM stage. The expression of Prox-1 can be one of important prognostic factors for colon cancer.
Keywords：Prox-1Colon cancerLymphatic metastasis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 83-85,104 )