To evaluate the efficacy of primaquine and artemether combined treatment of falciparum malaria

SI Huiyuan; LI Xiaojuan; YAO Ning; ZHOU Ping; SUN Ying

Abstract：Objective To evaluate the efficacy of primaquine and artemether combined treatment of falciparum malaria. Methods Selected patients who were hospitalized in Sino-Tanzania Friendship Hospital with falciparum malaria, collecting in time for the 2013 May to 2014 March, a total of 100 cases, among whom 86 were Tanzanian and 14 were Chinese. The patients were divided into 2 groups: 50 cases in the combined group, 50 cases in the control group. For combined therapy group, intramuscular injection of 80mg artemether was used once a day, for 7 consecutive days, the first dose of 160 mg, 22.5 mg primaquine was used once a day in the first days of taking artemether, lasting for 8 days; for the control group treatment: intramuscular injection of 80 mg artemether was used once a day for 7 consecutive days, with the first dose of 160 mg. The efficacy of hospital treatment in the two groups (recovery, invalid, reheat) and adverse reaction were evaluated. Results The combined group and the control group is invalid (98%, 0, 2%; 82%, 4%, 14%), the combined group and the control group, statistically significant differences is invalid, or (P<0.05); the incidence of adverse reaction in combined group and the control group was 8% and 16% respectively, the difference was statistically significant (P<0.05). Conclusion Primaquine and artemether combined therapy can improve the curative effect in the treatment of falciparum malaria, and reduce the probability of relapse, less adverse reaction.