Analysis of the change of cartilage matrix components and related growth factors and inflammatory factors in temporomandibular joint affecting under sustained high acceleration
CHEN Xin
LI Hongshi
FENG Yan
YIN Yin
CAO Junkai
Abstract：Objective To investigate possible changes of cartilage matrix components typeⅡcollagen, polysaccharides, chitosan body and IGF-1, collagenase TGF-β1, TNF-α, IL-2 and IL-3 on temporomandibular joint disorder (TMD) under the establishment of different persistent high acceleration (+Gz) animal model of environment and the different activated time condition. Methods 36 Rats were randomly divided into 3 groups: Sham group(n=12), +5 Gz group(n=12), and +10 Gz group(n=12), isolated and temporomandibular cartilage cells of normal and high acceleration in vitro, extraction of total mRNA, fluorescence quantitative PCR detection. Results TypeⅡcollagen, polysaccharides, chitosan body and IGF-1, collagenase TGF-β1 decreased significantly, while TNF-α, IL-2 and IL-3 increased significantly. Conclusion The decrease of collagen type Ⅱ, proteoglycans, collagenase, IGF-1, TGF-β1 and increase of IL-2, IL-3 could be very important reasons for the reconstruction and inflammation reaction of proteoglycans induced by repeated +Gz stresses on temporomandibular joint.
Keywords：Persistent high acceleration (+Gz)Temporomandibular joint cartilage matrix componentsInflammatory factor
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 13-16 )