Correlation of plasma omentin-1 and diabetic nephropathy in type2 diabetic patients

HUANG Xian-zhen

Abstract：Objective To explore correlation of omentin-1 and diabetic nephropathy in type 2 diabetic patients. Method Plasma omentin-1 levels were measured by enzyme linked immunosorbent assay(ELISA) in 51 type 2 diabetic patients without diabetic nephropathy and 46 diabetic nephropathy in type 2 diabetic patients(group B),as well as 61 normal healthy individuals as controls(group NC).In addition, glucose and lipid metabolism parameters and morphological characters were assessed. Finally, multivariate logistic regression analysis was used to explore the risk fact for coronary heart disease in central obesity. Result The serum plasma omentin-1 level of group B was much lower than those of group NC and group A(P<0.05,P<0.01).However,there was no difference in omentin-1 level between group NC and group A(P>0.05). Multivariate logistic regression analysis revealed that waist circumference and Triglyceride were independent risk factors of diabetic nephropathy in type 2 diabetic patients(OR=1.489,95%CI:1.145~1.833,P=0.041; OR=1.766,95%CI: 1.244~2.288,P=0.031),while plasma omentin-1 was an independent protective factor(OR=0.588,95%CI:0.346~0.830,P=0.000). Conclusion It suggests that detection of plasma omentin-1 level may play an important role in early diagnosis and prevention of diabetic nephropathy in type 2 diabetic patients.