Changes in positive acceleration environment on interleukin-6 and myocardial mitochondrial of miniature swine accompanying coronary artery stenosis

LIYa-ping; ZHANGHai-tao; LUOHui-lan

Abstract：Objective To study the effect of interleukin-6(IL-6) and myocardial mitochondrial of miniature swine model accompanying coronary stenosis at different levels under positive acceleration(+Gz). Methods Bama miniature swine were taken as study object to establishing the model of left anterior descending wire cerclage artery stenosis at different levels,and exposed to +Gz,the maximum tolerated acceleration value and IL-6 levels before and after centrifugation were observed in each group; then myocardial mitochondria of anterior wall tissue of left ventricular were observed under electron microscopes. Results The IL-6 levels rise linearly each group exposed to the maximum tolerated acceleration. There is significant difference on IL-6 levels in different groups of porcine model exposed to the maximum tolerated acceleration,compared with the normal control group IL-6 levels in the moderate and the severe groups were significantly raised,but the mild was not. The mitochondrial morphology is nomal in contorl group. The mitochondrial arrange was disorderly slightly,the cristae was slightly fuzzy in mild stenosis group. The mitochondrial cristae was vague, vacuolation in moderate stenosis group. The mitochondrial cristae was significantly fuzzy,more vacuolation, and even rupture in severe stenosis group. Conclusions There was no significant change about IL-6 and myocardial mitochondria in mild stenosis group exposed to +Gz. There were IL-6 increased significantly and myocardial mitochondria injury obviously in the moderate stenosis group and severe groups;and coronary artery stenosis was heavier, IL-6 increased more significantly and myocardial mitochondria changed more obvious.