Use of liquid based cytology and DNA ploidy analysis in screening cervical lesions

JIHui-zhen; LIDe-chang

Abstract：Objective We aimed to investigate an effective approach to improve detection rate for screening the cervical lesions. Methods The TCT analysis,DNA ploidy analysis were used to screen the women coming to our Health Check Centre. Results The detection rate of TCT abnormalities was 6%(720/12 000) ,of which detection rate of ASC-US was 2.5%(300/12 000) ,LSIL was 2.1%(252/12 000) ,HSIL and above were 1.4%(168/12 000). The abnormal DNA ploidy analysis occurred in 5.94%(713/12 000). For the TCT analysis,the sensitivity of 58.0%,the peculiarity of 88.0%,the positive predictive value of 73.1%,the negative predictive value of 79.6%were calculated for cases of CINI or above;for DNA ploidy analysis,the sensitivity of 80.1%and specificity of 70.1%and positive predictive value of 59.1%and negative predictive value of 86.7%were calculated for cases of CINI or above;for TCT combined with the DNA ploidy analysis,sensitivity of 81.4%,the peculiarity of 65.7%,the positive predictive value of 56.2%,the negative predictive value of 86.7%were calculated for cases of CINI or above. Conclusion The TCT screening combined with DNA ploidy analysis might improve the detection rate of cervical precancerous lesions and early cervical carcinoma.