The mechanisms of cell apoptosis in alveolar bone destroy and repair in diabetic periodontitis
DENG Tian-zheng
LI Dong-xia
FENG Yan
KEJie
ZHAO Gui-zhi
Abstract：Objective We planned to discuss the possible mechanisms of cell apoptosis in diabetic periodontitis. Method We reduced the diabetics periodontitis in rats by Streptozocin and steel wire and analyzed apoptosis in this animal model. Result Diabetes increased the intensity and duration of the inflammatory infiltrate (P<0.01). The formation of osteoclasts and percent eroded bone in the diabetic group were significantly higher than the control group (P>0.05). Diabetes also increased apoptosis and reduced the number of osteoblasts, and periodontal ligament fibroblasts (P<0.05). Conclusion An induced periodontal destruction in rats by significantly increasing the inflammatory response, and enhancing cell apoptosis through a caspase-3-dependent mechanism. Antibiotics had more effect on hyperglycemia than in normoglycemic rats.
Keywords：Aggregatibacter actinomycetemcomitansPeriodontitisApoptosisHyperglycemia
Publication Date：2013-07-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 146-148,160 )