The study of joint functional recovery repaired by tissue engineering osteochondral composites
DENG Tian-zheng
LV Jing
LI Dong-xia
YANG Jie-fei
KE Jie
Abstract： Objective We aimed to discuss the results of anatomical osteochondral composites in repairing large articular joint defects. Methods We prepared gelatin-chondroitin sulfate-hyaluronic acid and gelatin-ceramic anatomical shape osteochondral composites scaffold, and divided the patients into composite cell group, no cell group and not repair group. In situ transplantation in the body, observe the general view, movement function, HE dyeing, and O'Driscoll score after surgery in the different time. Results In experiment group there was obstacle in movement function. When they were walking, lower limb movement was symmetrical, general view was as normal as nature joint, surface layer presented slightly hyaline cartilage, and normal tissue boundary was not obvious. HE stain showed organization structure’s gradual renovation and its similarity to natural joints. Conclusion Anatomical composite tissue played a key role in function recovery through the postoperative movement function, and general observation. However, it still needed further deepening research.
Keywords：Snatomical shapeOsteochondralTissue-engineeringFunctional recovery
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 41-45 )