The Influence of Serum CTRP15,BACH1 and TRAIL Levels on Cardiac Function and Prognosis in Patients with Acute Myocardial Infarction

JING Jing; LI Jinbei; ZHANG Weiguo

doi:10.3969/j.issn.2096-305X.2026.01.006

Abstract：Objective To explore the evaluation value of serum levels of C1q tumor necrosis factor-related protein 15(CTRP15),BTB-CNC homolog 1(BACH1),and tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)for the cardiac function and prognosis of patients with acute myocardial infarction(AMI).Methods A total of 151 AMI patients admitted to the Sixth Ward of the Department of Cardiovascular Medicine of the Second Affiliated Hospital of Zhengzhou University from September 2022 to June 2024 were selected as the AMI group.They were divided into the good prognosis group and the poor prognosis group based on the prognosis.Another 100 healthy individuals undergoing physical examinations were selected as the control group.Color Doppler ultrasound was used to detect the cardiac function of the subjects.Enzyme-linked immunosorbnent assay(ELISA)method was used to detect the levels of serum CTRP15,BACH1,and TRAIL.The data and serum CTRP15,BACH1,and TRAIL levels of the AMI group and the control group were compared.The cardiac function parameters of the AMI group and the control group were compared.The serum CTRP15,BACH1,and TRAIL levels of patients with different cardiac function grades were compared.Pearson correlation analysis was used to analyze the correlation between serum CTRP15,BACH1,and TRAIL levels and cardiac function parameters.The incidence of poor prognosis in AMI patients was recorded.The data and serum CTRP15,BACH1,and TRAIL levels of patients with different prognoses were compared.The influencing factors of poor prognosis in AMI patients were analyzed using multivariate Logistic regression.The predictive value of serum CTRP15,BACH1,and TRAIL levels for poor prognosis in AMI patients was analyzed using receiver operating characteristic(ROC)curve analysis.Results The serum BACH1 level of patients in the AMI group was higher than that of the control group,while the serum levels of CTRP15 and TRAIL were lower than those of the control group(P＜0.05).The LVEF level of patients in the AMI group was lower than that of the control group,while left ventricular end diastolic dimension(LVDD)and left ventricular posterior wall thickness(LVPWT)levels were higher than those of the control group(P＜0.05).The higher the cardiac function grade of AMI patients,the higher the serum BACH1 level,and the lower the serum CTRP15 and TRAIL levels(P＜0.05).The levels of serum CTRP15,BACH1 and TRAIL are closely related to the cardiac function parameters of AMI patients(P＜0.05).The incidence of poor prognosis in AMI patients is 31.79%.The serum BACH1 level in the poor prognosis group is higher than that in the good prognosis group,while the serum CTRP15 and TRAIL levels are lower than those in the good prognosis group(P＜0.05).The levels of serum CTRP15,BACH1 and TRAIL are influencing factors for poor prognosis in AMI patients(P＜0.05).The joint of serum CTRP15,BACH1,and TRAIL levels had a higher value in predicting poor prognosis in AMI patients than individual predictions(ZCTRP15-joint prediction,ZBACH1-joint prediction,ZTRAIL-joint prediction=2.671,3.202,2.246;PCTRP15-joint prediction,PBACH1-joint prediction,PTRAIL-joint prediction=0.008,0.001,0.025).Conclusion Serum BACH1 is elevated in AMI patients,while serum CTRP15 and TRAIL are reduced.The levels of the three factors are closely related to the cardiac function and prognosis of AMI patients,and the joint of the three factors has a high value in predicting poor prognosis of AMI patients.