The Relationship Between Plasma IL-6 Levels and Anticoagulant Protein Levels in Sepsis Patients

MAO Tingting; HAN Kunyuan; SONG Honglin; DONG Zhipeng; WANG Fei

doi:10.3969/j.issn.2096-305X.2025.06.008

Abstract：Objective To explore the relationship between plasma IL-6 levels and anticoagulant protein levels in sepsis patients.Methods A total of 83 patients with sepsis who were treated in the Intensive Care Units(ICU)of Anyang People's Hospital from January 2024 to May 2025 were selected.According to the interleukin-6(IL-6)level(with 32.1 pg/mL as the critical value),the patients were divided into the low IL-6 level group(n=28)and the high IL-6 level group(n=55),and the differences in anticoagulant protein levels between the two groups were analyzed.Based on the death status within 30 days after the diagnosis of sepsis,the patients were divided into the death group(n=18)and the survival group(n=65).The relationship between IL-6 levels and anticoagulant protein levels was compared between the two groups.Results The procalcitonin(PCT)(79.12±29.81)ng/mL,C-reactiveprotein(CRP)(173.33±63.37)mg/L,sequential organ failure assessment(SOFA)score(9.05±3.81)points,and APACHE Ⅱ score(19.46±5.18)points in the high IL-6 level group were significantly higher than those in the low IL-6 level group(P＜0.05).In this study,a total of 18 cases died,with a mortality rate of 21.60％.The survival rate of the high IL-6 level group(70.00％)was significantly lower than that of the low IL-6 level group(90.91％)(P＜0.05).The levels of Protein C(PC)(37.53±13.27)％,Prtein S(PS)(69.06±13.28)％,and antithrombin Ⅲ(AT-Ⅲ)(56.15±12.19)％,in the high IL-6 level group were significantly lower than those in the low IL-6 level group.In the sepsis death group,the levels of PC(34.37±9.19)％,PS(68.38±8.47)％,and AT-Ⅲ(49.65±10.45)％,in the high IL-6 level group were significantly lower than those in the low IL-6 level group(P＜0.05).The high IL-6 level group in the sepsis survival group had significantly lower levels of PC(42.35±15.18)％,PS(72.42±10.35)％,and AT-Ⅲ(60.46±9.33)％compared to the low IL-6 level group(P＜0.05).Pearson correlation analysis revealed that IL-6 was significantly negatively correlated with PC(r=-0.623,P＜0.001),AT-Ⅲ(r=-0.598,P＜0.001),and PS(r=-0.112,P=0.025).Conclusion The elevated level of IL-6 in patients with sepsis is a factor influencing anticoagulant proteins(PC,AT-Ⅲ and PS).It can serve as a key early warning indicator for the deterioration and prognosis of sepsis-induced coagulopathy,and is beneficial for monitoring the changes in the condition of sepsis patients in clinical practice.