The Impact of Soothing the Liver and Relieving Depression Method on Appetite-regulating Hormones in Patients with Obesity
YOU Xiaoke
WEN Xinli
FAN Huijie
FAN Qianying
LI Ting
Abstract：Objective To explore the impact of the liver-soothing and depression-relieving therapy on the appetite-regulating hormones of obese patients based on the brain-gut axis.Methods From October 2022 to October 2024,97 obese patients who received medical treatment at Zhengzhou People's Hospital were selected as the subjects of this study.Using the random number table method,the patients were divided into the treatment group and the control group,with 49 and 48 cases respectively.The control group received conventional exercise and dietary intervention,while the treatment group received conventional intervention in addition to taking traditional Chinese medicine prescriptions for soothing the liver and relieving depression.The morphological indicators,clinical treatment effects,TCM syndrome scores,appetite-regulating hormone levels,and brain-gut axis-related indicators of the two groups were compared.Results After treatment,the body mass index(BMI)(23.82±2.68)kg/m2,weight(63.71±6.32)kg,waist circumference(88.33±5.07)cm,and hip circumference(91.61±4.73)cm of the treatment group were significantly lower than those of the control group(P＜0.05);the therapeutic group(95.92％)showed significantly better efficacy than the control group(P＜0.05);in terms of the integrated Chinese medicine syndrome scores,the treatment group(4.69±2.47)scored lower than the control group(P＜0.05);the levels of leptin(3.27±0.18),ghrelin(3.48±0.28),and peptide YY(PYY)(2.17±0.28)in the treatment group were higher than those in the control group(P＜0.05);the Substance P(SP)level in the treatment group(75.25±5.65)pg/mL was lower than that in the control group.Moreover,the neuropeptide Y(NPY)level(206.27±20.98)g/mL and the 5-hydroxytryptamine(5-HT)level(48.35±5.60)pg/mL in this group were higher than those in the control group(P＜0.05).Conclusion The liver-soothing and depression-relieving therapy combined with conventional interventions effectively improves anthropometric parameters,modulates appetite-regulating hormones and brain-gut axis-related neurotransmitters,and significantly enhances clinical outcomes in obese patients,demonstrating the potential of integrated Chinese and Western medicine approaches for obesity management.
Keywords：brain-gut axisliver drainage methodobesityappetite regulation hormone
Publication Date：2025-12-30
Online Publishing Date：2026-04-02(First online date of this platform, not the publication date of the document)
Pages：6( 49-54 )