Effect of bFGF Gel on Epidermal Barrier Function of Facial Acne Scar After Laser Treatment
SUN Lu
WANG Zhexin
JIA Yali
LI Yang
Abstract：Objective To explore the adjuvant therapeutic effect of bovine basic fibroblast growth factor gel on facial acne scar after dot matrix laser treatment.Methods 80 patients with facial acne scars received in our hospital from June 2022 to June 2024 were selected as the research object.They were divided into two groups by drawing lots,40 cases in each group.All patients were treated with dot matrix laser,and the control group was given collagen dressing,while the observation group was treated with bovine basic fibroblast growth factor gel.The clinical effect,Echelle D'Evaluation Clinique des Cicatrices D'Acne(ECCA)grading scale,scab peeling time(SPT),skin barrier function(SBF),scar symptom score(SSS),collagen Ⅰ(COL Ⅰ),collagen Ⅱ(COL Ⅱ)transforming growth factor-beta 1(TGF-β1),transforming growth factor-β-Activated kinase 1(TAK1)and vascular endothelial growth factor(VEGF)were compared between the two groups.Results The total effective rate in the observation group was 92.50％,which was significantly higher than that in the control group(P＜0.05).After treatment,the score of ECCA in the observation group was(11.00±1.97)and the scab peeling time was(6.55±0.90)d,which was significantly lower than that in the control group(P＜0.05).After treatment,the oil(56.42±2.94)AU,epidermal water loss(18.51±2.01)g/(h·m2)and scar symptom score(15.38±3.99)in the observation group were significantly lower than those in the control group.The skin moisture content(49.68±4.28)AU in this group was significantly higher than that in the control group(P＜0.05).Type Ⅰ collagen(57.58±9.34)μg/mg and type Ⅲ collagen(26.32±5.21)μg/mg in the observation group were significantly lower than those in the control group(P＜0.05).TGF(31.58±5.86)μg/mg,TAK(22.36±3.64)μg/mg and VEGF(77.81±10.35)μg/mg in the observation group were significantly lower than those in the control group(P＜0.05).Conclusion Bovine basic fibroblast growth factor gel can significantly improve the therapeutic effect,improve the epidermal barrier function of patients,alleviate scar symptoms and adjust the level of related growth factors as an auxiliary treatment after dot matrix laser treatment of facial acne scars.
Keywords：bovine basic fibroblast growth factor gelacne scarepidermal barriertherapeutic effect
Publication Date：2025-10-30
Online Publishing Date：2025-11-20(First online date of this platform, not the publication date of the document)
Pages：5( 93-97 )