Analysis of the Influencing Factors of Anxiety in Patients with Parkinson's Disease
HE Chang
XIN Yuting
ZHANG Yushan
KONG Junyan
YANG Zi
CHENG Yu
XU Wei
Abstract：Objective To analyze the clinical characteristics and influencing factors of anxiety in patients with Parkinson's disease(PD)and provide evidence for improving their quality of life.Methods A total of 115 PD patients were recruited from the Parkinson's Disease Specialty Clinic of the First Affiliated Hospital of Jinzhou Medical University between September 2023 and September 2024.Demographic data(e.g.,sex,age,disease duration),motor/non-motor symptom assessments(via standardized scales),and inflammatory markers were collected.Patients were divided into anxiety and non-anxiety groups based on Hamilton Anxiety Rating Scale(HAMA)scores,and the anxiety group was further stratified into three severity levels:possible anxiety,probable anxiety,and marked anxiety.Univariate and multivariate Logistic regression analyses were performed to identify risk factors,and the predictive value was evaluated using receiver operating characteristic(ROC)curve analysis.Results PD-A patients exhibited higher scores on the MDS-UPDRS-Ⅲ,HAMD,PSQI,SCOPA-AUT,CCS,and FS-14 scales,as well as elevated levels of CRP and IBI,but lower levels of IL-6.MDS-UPDRS-Ⅲ score(OR=1.176,P=0.006),HAMD score(OR=1.181,P=0.015),IL-6 level(OR=0.904,P=0.014),and IBI level(OR=1.017,P=0.044)were identified as independent predictors of PD-A.The combined predictive model demonstrated good performance,with an AUC of 0.833.Additionally,MDS-UPDRS-Ⅲscore(OR=1.439,P＜0.001)was an independent risk factor for the severity of PD-A.Conclusion PD-A patients experience more severe motor and non-motor symptoms,along with higher levels of systemic inflammation.Motor dysfunction,depressive symptoms,IL-6,and IBI levels are independent predictors of PD-A,and the combined predictive model shows high clinical value.Motor dysfunction is a key factor influencing the severity of PD-A.
Keywords：Parkinson's diseaseanxietyinflammatory factors
Publication Date：2025-10-30
Online Publishing Date：2025-11-20(First online date of this platform, not the publication date of the document)
Pages：8( 65-72 )