The Effect of Modified Endoscopic Mucosal Resection on Surgical Stress Response and Gastrointestinal Function in Elderly Patients with Gastrointestinal Polyps

LIANG Haijian; DONG Shihai; LIU Yong

doi:10.3969/j.issn.2096-305X.2025.05.009

Abstract：Objective To explore the effect of modified endoscopic mucosal resection on surgical stress response and gastrointestinal function in elderly patients with gastrointestinal polyps.Methods A total of 120 elderly patients with gastrointestinal polyps admitted to our hospital from January 2022 to December 2023 were randomly selected for this study.The patients were divided into two groups using the random number table method.Among them,60 patients in the control group received conventional treatment,while 60 patients in the observation group underwent modified endoscopic submucosal dissection.The cortisol(Cor),norepinephrine(NE),creatine kinase(CK)levels,the one-time resection rate of polyps,and the amplitude of the ascending colon and transverse colon were compared between the two groups of patients regarding their surgical stress response indicators.Results The one-time resection rate of polyps in the observation group was 98.33％(59/60),significantly higher than that in the control group which was 85.00％(51/60).The difference was statistically significant(x2=5.125,P=0.014).After the operation,the amplitude of the ascending colon(123.15±13.46)μV and the amplitude of the transverse colon(6.14±0.75)per minute in the observation group were significantly lower than those in the control group[(137.24±14.57)μV,(7.28±0.83)times/minute],and the difference was statistically significant(t=5.237/6.392,P＜0.001).The postoperative Cor(175.03±12.34)ng/mL,NE(44.19±5.48)ng/mL,and CK(179.58±21.34)U/L expression levels in the observation group were lower than those in the control group(213.51±12.41)mg/mL,(52.32±5.53)ng/mL,and(223.23±21.13)U/L,and the differences were statistically significant(t=9.648,5.427,8.075,P＜0.001).Conclusion Modified endoscopic mucosal resection can effectively reduce surgical stress response,and improve postoperative gastrointestinal function in patients with gastrointestinal polyps.