Correlation Analysis Between Progressive Stroke and Serum Free Fatty Acids
MA Ning
YANG Bo
ZHANG Fan
SUI Rubo
Abstract：Objective To discuss the correlation between serum free fatty acids and acute progressive ischemic stroke,and explore the significance of changes in characteristic serum fatty acid profiles and serum free fatty acid levels in patients with acute progressive ischemic stroke,so as to provide reference for targeted clinical intervention.Methods A total of 130 patients with acute ischemic stroke hospitalized in the First Affiliated Hospital of Jinzhou Medical University from January 2023 to October 2023 were selected,among which 65 patients with acute progressive ischemic stroke were taken as the study group and 65 patients with non-progressive acute ischemic patients were taken as the control group.The free fatty acids of the patients were detected by liquid chromatography tandem mass spectrometry.It includes palmitic acid,linolenic acid,linoleic acid,oleic acid,eicosapentaenoic acid(C20∶5),docosahexaenoic acid(C22∶6),total saturated fatty acids,total monounsaturated fatty acids,total ω3 and total ω6.SPSS soft was used for statistical analysis.Results Compared with the control group,the levels of palmitic acid and linoleic acid in the serum of the study group were higher,with statistically significant differences(P＜0.05).The levels of eicosapentaenoic acid(C20∶5),docosahexaenoic acid(C22∶6),and total ω3 in the study group were lower than those in the control group,with statistically significant differences(P＜0.05).However,there were no statistically significant differences in the levels of the other fatty acids(all P＞0.05).Multivariate regression analysis further confirmed that the above five serum free fatty acid metabolites were correlated with progressive stroke.The correlation analysis of serum free fatty acids and the increase in NIHSS score in the study group indicated that palmitic acid was positively correlated with the increase in NIHSS score;total ω3,eicosapentaenoic acid(C20∶5),and docosahexaenoic acid(C22∶6)were negatively correlated with the increase in NIHSS score;while linoleic acid was not correlated with the increase in NIHSS score.Conclusion Serum free fatty acid levels are correlated with progressive ischemic stroke.Changes in palmitic acid,linoleic acid,total 3,eicosapentaenoic acid(C20∶5),and docosahexaenoic acid(C22∶6)can serve as potential markers for patients with acute progressive ischemic stroke.
Keywords：acute ischemic strokeacute progressive ischemic strokeserum fatty acidrisk factors
Publication Date：2025-08-30
Online Publishing Date：2025-10-17(First online date of this platform, not the publication date of the document)
Pages：6( 90-95 )