Research on the Correlation Between Serum Selenium Level in Early Pregnancy and Gestational Diabetes Mellitus

YANG Yan; ZHANG Chunlan; CHEN Kaijie; YANG Jinmei

doi:10.3969/j.issn.2096-305X.2025.01.016

Abstract：Objective To explore the correlation between serum selenium level in early pregnancy and gestational diabetes mellitus(GDM).Methods Pregnant women who were first confirmed pregnant in the obstetrics clinic of our hospital from January 2021 to May 2022 were selected as the study objects.Serum selenium levels and other related indicators in the early gestation period(6-14 weeks of gestation)of all pregnant women were detected,and they were divided into GDM group and control group according to whether they were diagnosed with GDM.The relevant data of the two groups were compared,the influencing factors of GDM in pregnant women were analyzed by Logistic multivariate regression model,and the predictive value of serum selenium level to GDM was analyzed by receiver operating characteristic(ROC)curve.Results Among the 340 pregnant women included in the analysis,the incidence of GDM was21.18%(72 in GDM group and268 in control group).The age,pre-pregnancy body mass index(BMI),proportion of multipara,fasting blood glucose(FPG),glycosylated hemoglobin(HbA1c)and fasting insulin(FINS)levels in GDM group were significantly higher than those in control group(P<0.05).The serum selenium level in the GDM group was lower than that in the control group(P<0.05).Logistic multivariate regression analysis showed that age,pre-pregnancy BMI(OR=1.190,95%CI:1.025-1.494),FPG(OR=1.408,95%CI:1.121-1.767),HbA1c(OR=2.125,95%CI:1.237-3.651)and serum selenium level(OR=0.381,95%CI:0.222-0.654)were the influencing factors of GDM in pregnant women(P<0.05).ROC curve showed that the area under the curve(AUC)of serum selenium level in early pregnancy to predict GDM was 0.932,the sensitivity and specificity were 83.33%and 91.42%,respectively.Conclusion Serum selenium level in early pregnancy is an independent factor of GDM,and increasing its level can reduce the risk of GDM.Detection of serum selenium level has high application value in predicting the occurrence of GDM.