Changes and Clinical Significance of Laboratory Indicators of Acute Benign Myositis

WANG Mengdi; LI Jing

doi:10.3969/j.issn.2096-305X.2025.01.011

Abstract：Objective To explore the significance and value of laboratory indexes in the occurrence and development of benign myositis through studying the changes of relevant laboratory indexes in children with benign myositis.Methods A total of 29 children with acute benign myositis who were hospitalized in the Department of Pediatrics of the First Affiliated Hospital of Jinzhou Medical University from October 2022 to March 2023 were selected as the study objects.These children were included in the case group,including 19 males and 10 females,aged from 3 to 13 years,with an average age of 4 years.For comparative analysis,another 29 healthy children were selected as the control group,including male(13 cases)and 16 female(16 cases),aged from 1 to 12 years old with an average age of 3 years old.Clinical and laboratory data,such as sex,age,height,weight,body mass index(BMI),creatine kinase(CK),myoglobin(Mb)and creatine kinase isoenzyme MB(CK-MB)were collected for the two groups of children.To ensure the accuracy and reliability of the data,SPSS software was used for statistical analysis.Results No statistical difference was found in the analysis of general data between the two groups.Compared with the healthy control group,the myocardial enzymology test results of 29 cases showed that the concentrations of CK and Mb increased sharply within 24 h after the onset of benign myalgia symptoms,both of which were more than 10 times the normal level.Subsequently,the concentration of these enzymes gradually fell back.CK and Mb concentrations remained higher than normal,and there was no significant difference(P>0.05).Analysis of sensitivity data showed that there was no statistically significant difference between Mb and CK concentrations within 24 h after onset.Compared with the concentration of CK-MB,the difference was statistically significant(P<0.001).On the 4th day of onset,the concentration changes of Mb and CK were statistically significant(P<0.05).Conclusion The occurrence of benign myositis can be attributed to a variety of pathogens,including,but not limited to,influenza viruses,EBV,mycoplasma,and even bacterial infections.Its clinical manifestations are mainly myalgia of varying degrees,accompanied by significant increases in creatine kinase and myoglobin.Early detection and dynamic monitoring of these two biochemical indicators can play an early warning role in the diagnosis and development of myositis.