Analysis of Risk Factors of Liver Cirrhosis Complicated with Upper Gastrointestinal Bleeding

XIN Hongyue; SUN Yueting; HAO He; YAN Xue

doi:10.3969/j.issn.2096-305X.2025.01.010

Abstract：Objective To analyze and discuss the risk factors of upper gastrointestinal bleeding in liver cirrhosis by non-invasive examination.Methods Clinical data of 262 patients with hepatitis B,hepatitis C and alcoholic cirrhosis admitted and treated in our hospital from March 2021 to June 2023 were collected and divided into bleeding group(cirrhosis complicated with upper digestive tract hemorrhage,n=140)and non-bleeding group(cirrhosis,n=122).Data such as Age,gender,etiology,main admission symptoms,liver function Child-Pugh score,prothrombin time(PT),fibrinogen(Fib),alanine aminotransferase(ALT),aspartate aminotransferase(AST),and platele(PLT)and other data of the patients were collected.Univariate analysis and multiple Logistic regression analysis were used to find the influential factors of cirrhosis complicated with upper gastrointestinal bleeding.Results Univariate analysis showed that there was no significant difference in age,sex and etiology between the bleeding group and the non-bleeding group(P>0.05);there was no significant difference in fatigue among the main admission symptoms(P>0.05);there was no significant difference in serum indexes ALT,AST and PLT(P>0.05);the Child-Pugh score of liver function in bleeding group was higher than that in non-bleeding group,and the difference was statistically significant(P<0.05);among the main admission symptoms,abdominal distension and jaundice in the non-bleeding group were significantly higher than those in the bleeding group,with statistical significance(P<0.05);the serum index of bleeding group was significantly higher than that of non-bleeding group,and the level of Fib was significantly lower than that of non-bleeding group,with statistical significance(P<0.05).The Child-Pugh score,PT and Fib of liver function were compared by multivariate analysis:Child-Pugh score of liver function and PT were the risk factors for upper gastrointestinal bleeding in liver cirrhosis(OR=1.583,1.432),and the difference was statistically significant(P<0.05);Fib was a protective factor for upper gastrointestinal bleeding due to liver cirrhosis(OR=0.235),and the difference was statistically significant(P<0.05).Conclusion Liver function Child-Pugh score and PT are risk factors and Fib is the protective factor in patients with upper gastrointestinal bleeding in cirrhosis.