Mulberry Bark Qingfeihuatan Formula in the Treatment of Cough Variant Asthma on the Level of Eosinophils in the Sputum of Children

YUAN Junru; WANG Dongmei; HAN Shanshan; DU Xiaoya

doi:10.3969/j.issn.2096-305X.2025.01.008

Abstract：Objective To study the effect of mulberry bark qingfeihuatan formula on the level of eosinophils(EOS)in the sputum of children with cough variant asthma(CVA).Methods A total of 80 children with CVA treated in Zhengzhou People's Hospital from February 2022 to February 2024 were selected as observation objects,and were randomly divided into observation group and control group,with 40 cases in each group by digital random table method.The control group was given budesonide combined with montelukast sodium chewable tablets,and the observation group was given mulberry bark qingfeihuatan formula on the basis of the control group for continuous treatment for 7 days.The traditional Chinese medicine symptom scores,EOS in sputum and inflammatory factors[interleukin-5(IL-5),interleukin-4(IL-4)]levels,and lung function[forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC),peak expiratory flow(PEF)]of the two groups of children with CVA before and after treatment were compared,and the occurrence of adverse reactions during the treatment process was observed.Results After treatment,the TCM symptom score,EOS,IL-5 and IL-4 in sputum of CVA children in both groups were significantly decreased(P<0.05),and the observation group was lower than the control group(P<0.05),suggesting that the observation group had better effect of symptom relief and inflammation resolution;FEV1,FVC and PEF of CVA children in both groups were significantly increased(P<0.05),and the observation group was higher than the control group(P<0.05),suggesting that the observation group had a better effect on lung function;there was no significant difference in the total incidence of adverse reactions between the two groups of CVA children(P>0.05),suggesting that the safety of the treatment used in the two groups was good.Conclusion Mulberry bark qingfeihuatan formula in the treatment of children with CVA can effectively relieve clinical symptoms,improve lung function,reduce the level of EOS and inflammatory factors in sputum and has good safety.