The Prediction of C-reactive Protein Combined with White Blood Cell Parameters for Sepsis in Children with Upper Respiratory Tract Infection Caused by Mycoplasma Pneumoniae

CHEN Chen; CHEN Chuanping; ZHANG Guangman

Abstract：Objective To explore the predictive value of white blood cell parameters combined with C-reactive protein(CRP)for sepsis in children with upper respiratory tract infection caused by mycoplasma pneumoniae.Methods A total of 124 children with acute upper respiratory tract infection and positive mycoplasma pneumoniae IgM antibody were selected as the study objects from May 2018 to January 2022 in the Affiliated Hospital of West Anhui Health Vocational College.The patients with sepsis were divided into two groups according to whether they had sepsis or not.The patients with sepsis were treated as the observation group(n=35),and the patients without sepsis were treated as the control group(n=89).White blood cell(WBC),monocyte(Mon),lymphocyte(Lym),neutrophil(Neu),eosinophils(Eos),Basophil(Bas),neutrophil to lymphocyte ratio(NLR),monocyte to lymphocyte ratio(MLR)and CRP levels were detected and analyzed in each group.The risk factors of sepsis were analyzed by binary logistic regression,and the predictive value of single and combined indicators was analyzed by receiver operating characteristics(ROC)curve.Results The Lym,Eos,and CRP of the observation group were significantly higher than those of the control group,while the MLR was significantly lower than that of the control group(P＞0.05);there was no significant difference in age,gender,WBC,Neu,Mon,Bas,and NLR between the two groups(P＜0.05).Binary logistic regression analysis showed that Eos(OR=17.364,95％CI:1.113-270.845),CRP(OR=1.128,95％CI:1.055-1.206),and MLR(OR=0.005,95％CI:0.000-0.362)were all risk factors for sepsis in children with upper respiratory tract infections caused by mycoplasma pneumoniae.ROC curve analysis showed that Eos,CRP and MLR predicted the area under curve of sepsis in children with upper respiratory tract infection with mycoplasma pneumoniae.AUC was 0.677,0.700 and 0.647,respectively.The AUC of Eos+CRP+MLR combined prediction was 0.843,which was significantly higher than that of single prediction(P＜0.05),and the sensitivity and specificity of combined prediction were 77.10％and 75.30％,respectively.Conclusion TEos,CRP,and MLR are all risk factors for sepsis in children with upper respiratory tract infections caused by mycoplasma pneumoniae.The combined detection of Eos,CRP,and MLR can improve the predictive value of acute upper respiratory tract infections progressing to sepsis.