Safety and Efficacy Analysis of Ciprofol in Inducing General Anesthesia Patients

ZHANG Dongbo; WU Qiaoling; SHEN Tu; LIU Feifei

Abstract：Objective To study the anesthesia effect of ciprofol and its influence on hemodynamics during anesthesia induction.Methods A total of 150 patients with grade Ⅰ or Ⅱ of American Standards Association(ASA)requiring tracheal intubation in the First Affiliated Hospital of Jinzhou Medical University from February 2023 to July 2023 were selected in a randomized,double-blind,controlled way and randomly divided into 3 groups.CP group(cyclopofol experimental group):0.4 mg/kg cyclopofol induction;group E(etomidate control group):0.3 mg/kg etomidate induction;group P(propofol control group):Propofol 2 mg/kg induction.The successful sedation of patients,the number of cases and times of drug addition during the induction period,the time from the beginning of induction to the disappearance of eyelash reflex,the time from the beginning of induction to BIS≤60,and the value of bispectral index(BIS)immediately after endotracheal intubation were recorded.At the same time,the changes of heart rate and mean arterial pressure were recorded at 4 min before anesthesia induction(T0),when eyelash reflex disappeared(T1),when tracheal intubation was completed(T2),and 4 min after tracheal intubation(T3);adverse reactions such as injection pain,hypotension,sinus bradycardia and sinus tachycardia were observed;the adverse reactions,such as restlessness,nausea and vomiting,were observed during the recovery period.Results The success rate of drug sedation in the 3 groups was 100％,and no sedation drugs were added.The time from induction to eyelash reflex disappearance and the successful anesthesia time in CP group were longer than those in E and P groups(P＜0.05),the heart rate changes in CP group were not significantly different from those in P group(P＞0.05),and the heart rate at T2 was lower than that in E group(P＜0.05).The decrease of mean arterial pressure in CP group was not significantly different from that in P group(P＞0.05),and was lower than that in E group at T1 to T3(P＜0.05).The total incidence of adverse reactions in CP group was lower than that in E group and P group;the incidence of myoclonus(P＜0.05),nausea and vomiting(P＜0.05)during administration in CP group was significantly lower than that in E group,and the injection pain was significantly lower than that in P group(P＜0.05).Conclusion Cyclopofol,etomidate and propofol can meet the sedation needs and achieve effective anesthesia depth during anesthesia induction;the success time of cypofol is slightly longer than that of etomidate and propofol.Compared with etomidate,the blood pressure of patients induced by cipofol decrease more significantly.Etomidate is more likely to cause a significant increase in heart rate and blood pressure during tracheal intubation,and the incidence of etomidate myoclonus is the highest,and the incidence of tachycardia,nausea and vomiting is also higher than that of cipofol.Compared with propofol,the induced hemodynamic indexes of cyclopofol are similar to that of propofol.The incidence of pain and total complication of cyclopofol injection is much lower than that of propofol,and its safety is better than that of propofol.