Effects of Total Flavonoids from Polygonum Chinense L.on Mice Liver and Kidney
WANG Shuzhen
LIN Yanyan
ZHANG Qian
WANG Qiongjun
LIN Zeyan
Abstract：Objective To study the safety and dosage of total flavonoids from Polygonum chinense L.on liver and kidney.Methods The drug was administered by gavage for 15 days.Liver and kidney were extracted and weighed,and organ coefficients were calculated.Alanine aminotransferase(ALT),aspartate transaminase(AST),serum screatinine(Scr),blood urea nitrogen(BUN)levels were tested,and liver and kidney histological sections were performed.Results The liver coefficient of mice showed dose-bidirectional and spleen coefficient showed concentration negative effect;there was no significant difference between ALT,AST and control group,and there was statistical difference between Scr and control group,but there was no statistical difference between concentration.The BUN value of the low concentration group was significantly different from that of the control group,and the BUN value of the treatment group had a positive concentration effect(P＜0.05),but it was lower than that of the control group.The balloon change of liver tissue showed a positive concentration effect,and the kidney tissue had no significant change.Conclusion When the total flavonoids from Polygonum chinense L.are used in health food,the oral dose should not exceed 1 mg/kg.
Keywords：Polygonum chinense L.total flavonoidsmice liver and kidneybiochemical criterionhistopathology
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 30-33 )