Characterization of W/O Emulsion Electrospinning Poloxamer188® Composite Poly L-lactic Acid Fibers

CUI Kechang; LV Yunqi; DONG Xin; WANG Hao

Abstract：Objective To investigate the morphology and composite behavior of Poloxamer188® polylactic acid W/O emulsion electrospinning fibers.Methods Using Poloxamer188® as emulsifier and dichloromethane solution of Poloxamer188@and Poloxam-er188® as oil phase and pure water as water phase,W/O emulsion was prepared by ultrasonic emulsification technology under the con-dition of 1∶10 volume ratio of water phase to oil phase,and then electrospinning was carried out.The morphology of the spun prod-ucts was observed by optical microscopy,and the released Poloxamer188® was determined by infrared spectrums,differential thermal analysis,X-ray diffraction and complex-chromination-spectrophotometry,and the time-release percentage curve was drawn to charac-terize the material complex in detail.Results Ultra-fine fibers were obtained.With the increase of Poloxamer188® composite a-mount,infrared spectrums,differential thermal analysis curves and X-ray diffractograms all gradually showed characteristic peaks of Poloxamer188®.The burst release of Poloxamer188® from the fibers was considerable big followed by sustained release period of about 48 hours and then plateau period.As composite amount of Poloxamer188® increased,burst release amounts and plateau period release amounts became bigger and bigger even presenting linear relationships.Conclusion Emulsion electrospinning yields morphologically ideal ultra-fine fibers,and composite degrees of Poloxamer188®and poly L-lactic acid vary with the ratio of the former one.