The Effect of Nimodipine Combined with Alprostadil in the Treatment ofCerebral Vasospasm after Aneurysms Subarachnoid Hemorrhage
TAN Yangjin
WEN Shihong
ZHANG Jinxiang
Abstract：Objective To discuss the effect of nimodipine combined with alprostadil in the treatment of cerebral vasospasm (CVS) after aneurysms subarachnoid hemorrhage (aSAH).Methods From January 2012 to January 2016,72 cases of patients with CVS after aSAH in our hospital were selected and divided into two groups randomly.The control group (n=36) were treated with nimodipine only,while the observation group (n=36) were treated with nimodipine combined with alprostadil.The artery mean blood flows in two groups before and 1week,2 weeks after treatment were compared,and the prognosis status and the incidence of adverse reactions in two groups during treatment were compared as well.Results The mean blood flow velocity of anterior cerebral artery,posterior cerebral artery and middle cerebral artery in two groups 2 weeks after treatment was lower than that before and 1 week after treatment (P<0.05),and the observation group was lower than that in the control group (P<0.05).The cure rate of observation group was higher than that of control group (P<0.05),and the mortality rate was lower than that of control group (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion Nimodipine combined with alprostadil has good effect on prevention of CVS after aSAH.It can improve the prognosis and will not increase the adverse drug reaction,therefore,it is worthy of clinical promotion.
Keywords：nimodipinealprostadilcerebral vasospasmaneurysms subarachnoid hemorrhage
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 25-27 )