Research on Correlation Among Serum IGF-1,TNF-αand Atherosclerosis in Patients with Diabetes
LI Hui
ZHANG Di
ZHAO Hongxia
LI Jungai
GUO Chengda
Abstract：Objective To investigate the correlation among serum IGF-1,TNF-α and carotid atherosclerosis plaque in patients with diabetes.Methods The bilateral carotid intima-media thickness (IMT) of 233 patients were measured with ultrasound.According to the result of ultrasound,the patients were divided into case group with carotid atherosclerosis plaque (n=120) and control group without the plague (n=113),and the levels of serum IGF-1and TNF-α of the patients were determined with immunoradiometric assay.Results Compared with the control group,the case group had notably lowered IGF-1 level,with statistically significant difference (P<0.01).There was a negative correlation between IGF-1 level and the degree of carotid atherosclerosis plaque (P<0.01).The TNF-α level increased obviously in the case group in comparison with the other group,with statistically significant difference (P<0.01),presenting a positive correlation between TNF-α level the degree of carotid atherosclerosis plaque (P<0.01).Conclusion IGF-1 and TNF-α are involved in the occurrence and development of macroangiopathy in diabetes patients with atherosclerosis,and closely related to the degree of carotid atherosclerosis plaque.
Keywords：IGF-1TNF-αdiabetescarotid atherosclerosis plaque
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 22-24 )