Comparison Between Genistein and Daidzein inEffect on Ammonia-induced Astrocyte Swelling
JIA Guizhi
DAI Hongliang
Abstract：Objective To compare the inhibition of genistein and daidzein on ammonia-induced astrocyte swelling.Methods Cell viability was examined with MTT assay,cell swelling with3-O-methyl-[3H]-glucose.Co-immunoprecipitation was used to determine ERK/EGFR interaction.Results Genistein and daidzein at 50 μmol/L had no effect on astrocyte viability.Genistein,but not daidzein,produced significant inhibitory effect on ammonia-induced astrocyte swelling and ERK/EGFR interaction.Conclusion Genistein exhibits a significant inhibitory effect on ammonia-induced astrocyte swelling,which may be related to its specific inhibition on EGFR.
Keywords：genisteindaidzeinastrocyteswelling
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 7-9 )