The Research on the Correlation Between eNOS Polymorphisms and EssentialHypertension in Han Population in Western Liaoning Regions

ZHENG Xiaoming; SHAN Wei; LI Dehua; LIU Xue

Abstract：Objective This paper is intended to find out the relationship between essential hypertension (EH) and eNOS a/b polymorphisms by testing eNOS genes in patients with essential hypertension in Han population in western Liaoning regions.Methods A case-sibling control design was conducted between EH patients (217 cases) and those with normal blood pressure (206 cases),and Polymerase Chain Reaction (PCR) and gel electrophoresis were applied to test and analyze eNOS a/b polymorphisms.SPSS 11.5 was used in this research for data analysis.Result The test results from all studied targets showed that eNOS a/b polymorphisms genotype was significantly different from the genotype frequency of alleles when comparing EH group with the control group (genes:X2=3.812,P=0.016;alleles:X2=4.302,P=0.01).Single-factor logistic regression analyses for the testing data of all targets showed that as+ab genotype had significant correlation with EH,which was a dangerous factor for EH (OR=1.349,95％CI:1.032~2.006).Multivariate logistic regression analysis demonstrated that ages,fasting blood-glucose and eNOS a/b polymorphisms were independent factors for EH.And Meta analysis showed that eNOS a/b polymorphisms genotype frequency distributions were different when comparing the patients group with the control group,and people with aa+ab genotype were more prone to EH (OR=1.87,P<0.001).Conclusion eNOS a/b polymorphisms are closely related with the risk of developing EH among Han population in western Liaoning regions.