The Changes and Clinical Value of Plasma Lipoprotein Phospholipase A2 Level in Patients with Acute Arteriosclerosis Cerebral Infarction

ZENG Xiangfu; LIANG Tujin; LI Minghai; ZHU Qiuna

Abstract：Objective To analyze the changes and clinical value of plasma lipotrotein phospholipase A2 level ( LP-PLA2 ) in pa-tients with acute arteriosclerosis cerebral infarction ( ACI ) . Methods 115 cases with acute ACI were selected as the observation group, and 60 other cases were selected as the control group. The LP-PLA2 levels in two groups were compared and the changes of LP-PLA2 levels in patients with different infarct sizes and different degrees of neurological deficits were compared. In addition, the corre-lation of LP-PLA2 levels with patients’ age, sex, body mass index ( BMI) , smoking, systolic blood pressure ( SBP) , diastolic blood pressure ( DBP) , total cholesterol ( TC) , triglyceride ( TG) , high density lipoprotein cholesterol ( HDL-C) , low density lipoprotein cholesterol ( LDL-C) and C-reactive protein ( CRP) was analyzed. Results Compared with the control group, the LP-PLA2 level of the observation group increased significantly. LP-PLA2 level in patients with large infarcts increased significantly compared with that in patients with smaller infarct size. The differences in LP-PLA2 level among patients with varying degrees of neurological impairment were of statistical significance (P<0. 05). To be further, LP-PLA2 level gradually increased as patientsˊneurological impairment ag-gravated. Patients’ LP-PLA2 level had no significant correlation with patients’ sex, smoking, SBP, DBP and CRP (P>0. 05) and it had positive correlation with patients’ age, BMI, TC, TG and LDL-C (P<0. 05). Patients’ HDL-C was in negative correlation with LP-PLA2 level (P<0. 05). Conclusion LP-PLA2 is closely related to the infarct size, the degree of neurological deficit and biochemi-cal indexes of patients with acute arteriosclerosis cerebral infarction. By measuring LP-PLA2 level of patients with acute arteriosclerosis cerebral infarction, the development of the disease can be predicted. Therefore, it has certain clinical values.