Value of Combined Detection of MiR-210 and MiR-139-5 p in Early Diagnosis of Pre-eclampsia
ZHANG Yexia
FANG Zhenya
LI Rui
KONG Xiaoxia
ZHANG Jialun
WANG Zongjun
ZHANG Huiping
Abstract：Objective To explore the early diagnostic value of combined detection of miR-139-5p and miR-210 on patients with PE. Methods 30 patients with PE were chosen as PE group, 30 cases of normal parturiens as N group, 30 cases of non-preg-nant women as Z group, and the expression of miR-139-5p and miR-210 in serum of the three groups were examined by quantities re-verse transcription polymerase chain reaction (PCR), and ROC curve was used to analyze the diagnostic efficiency of miR-139-5P, miR210 and combined detection of miR-139-5p and miR-210 in PE. Results The quantities of expression on miR-139-5p and miR-210 of the PE group are significantly higher than those of the N and Z group, and ROC curve revealed that the areas under the ROC curve of miR-139-5P, miR-210 and combined detection of miR-139-5p and miR-210 for the diagnosis of PE were 0. 709, 0. 733 and 0. 771 respectively. Conclusion The combined detection of miR-139-5p and miR-210 is of great value in the early diag-nosis of PE.
Keywords：miR-139-5pmiR-210pre-eclampsia(PE)
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 22-26 )