Study on Clinical Effect of Alprostadil on Patients with Myocardial Infarction and its Influence Towards Hemorheology

LIANG Yucong; LIANG Jiahui; HU Jinghang; JIE Yingbiao

Abstract：Objective To study the clinical effect of Alprostadil on the patients with coronary heart disease ( CHD) and its influ-ence towards hemorhrology. Methods 106 CHD patients treated from March 2014 to March 2015 in our hospital were selected and randomly divided into two groups, 53 cases in each group. The patients in the control group were treated with the conventional thera-py, while those in the observation group were given Alprostadil on the basis of the conventional therapy. The clinical effect, blood lip-id, hemorheology and adverse reactions of two groups were observed. Results The total effective rate of observation group (86. 79%) was significantly higher than that of control group (69. 81%, P<0. 05). The difference of the blood lipid index (TC, TG, HDL-C, LDL-C) in the observation group before and after treatment was significantly higher than that in the control group ( P<0. 05 ) . The difference of the hemorheology index ( high shear blood viscosity, low shear blood viscosity, plasma viscosity, hematocrit, blood platelet aggregation rate, fibrinogen) in the observation group before and after treatment was significantly higher than that in the control group (P<0. 05). The incidence rate of adverse reactions as leukopenia, nausea, vomiting, vasculitis in observation group and con-trol group were 7. 55% and 5. 66% respectively, with no statistical difference ( P>0. 05 ) . Conclusion Alprostadil has an obvious effect on the patients with myocardial infarction, effectively reducing the blood lipid level and improving the abnormal blood stream. It is safe and worthy of clinical application and promotion.