Effects of Sevoflurane in Different Depth of Anesthesia on the Cognitive Function of Elderly Patients with Urological Surgery

CAI Yunliang; WANG Xianchun; pAN Chunjie; ZHU Hong; WANG Xin

Abstract：Objective To investigate the effects of Sevoflurane in Different Depth of Anesthesia? on the Cognitive Function of Elderly patients with Urological Surgery. Methods 80 elderly patients with urological surgery from June, 2014 to July, 2015 were selected. The patients were divided into observation? group (40 cases) and control group (40 cases) according to random number ta-ble. The patients in observation group received high concentrations of sevoflurane (BIS value was 35~45), while low concentrations of sevoflurane (BIS value was 50~60) in control group. Data were collected during the operations, amount of bleeding, intraopera-tive transfusion volume, number of low blood pressure, dose of remifentanil injection and end-expiratory sevoflurane concentration. Meanwhile, the mini mental state examination scale ( MMSE) was used to evaluate the cognitive function of preoperative 1 d as well as postoperative 1, 3 d and 7 d between the two groups. Results The differences in operation time, anesthesia time, amount of bleed-ing, intraoperative transfusion volume, number of low blood pressure, dose of remifentanil injection between the two groups were not statistically significant (P>0. 05). The difference in end-expiratory sevoflurane concentration between the two groups was statistically significant (P<0. 05). The scores of MMSE in postoperative 1, 3 d and 7 d of patients in the two groups were significantly lower than that before operation (P<0. 05). The incidence rate of pOCD in postoperative 1 d, 3 d in control group was significantly higher than that in observation group (P<0. 05), and the difference was statistically significant. The difference in the incidence rate of pOCD in postoperative 7 d between the two groups was not statistically significant (P>0. 05). Conclusions Sevoflurane is helpful to reduce the impact on postoperative cognitive dysfunction in elderly patients with urinary surgery in deep anesthesia.