Study of Mesoporous Silicon Improving the Dissolution Rate of Lovastatin
YU Tingting
Abstract：Objective To prepare mesoporous silicon ( FDU) for improving the dissolution rate of lovastatin ( LV) . Methods Template method was used to prepare FDU and take it as the carrier. LV was loaded into mesoporous structure by adsorption method. Morphology and structure of FDU were investigated by Transmission electron microscopy ( TEM) . The disperse state of LV in FDU-LV was identified by differential scanning calorimetry ( DSC) and X-ray diffraction ( XRD) . Dissolution test was used to investigate the in-vitro dissolution effect of FDU-LV powder sample. Results TEM images showed FDU had a nanoscale ordered mesoporous channel, and its nano scale mesoporous channel space inhibition effect can effectively inhibit the crystallinity of LV, LV existed in indefinite form. The in-vitro dissolution experiment demonstrated FDU significantly improved the dissolution rate of LV. Conclusion FDU ef-fectively improved the dissolution rate of LV.
Keywords：mesoporous siliconlovastatinpoorly water-soluble drugsdissolution rate
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 13-15 )