Preliminary Study of Inhibitory Effect of Genistein on Ammonia-induced Astrocyte Swelling
HAN Siyu
SUI Haijuan
JIA Guizhi
CHU Minghui
ZHENG Ru
SUN Yue
WANG Dandan
DAI Hongliang
Abstract：Objective To explore the protective effect of genistein on ammonia-induced astrocyte swelling preliminarily. Meth-ods Cell viability was examined through MTT assay and cell swelling was detected by calcein as a fluorescence probe. Results 50~200 μM genistein produced no effect on the viability of astrocyte, but inhibited ammonia-induced astrocyte swelling significantly. Thus its anti-edema activity is related to concentration. Conclusion Genistein can inhibit the swelling of astrocytes induced by ammonia and is expected to become a newly therapeutic agent for hepatic encephalopathy.
Keywords：genisteinastrocyteswelling
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 4-5,9 )