The Role of C-C Motif Chemokine Receptor-2 in Human Vein Endothelial Cells Migration
ZHAO Ning
ZHAO Lijie
Abstract：Objective To explore the effect of C-C motif chemokine receptor -2 ( CCR2 ) on the migration of human umbilical vein endothelial cells (HUVECs). Methods The effect of monocyte chemoattractant protein-1 (MCP1) on the expression of CCR2 in HUVECs was measured by RT-PCR and Western blot. The effect of anti-CCR2 polyclonal antibodies (RS504393) on the migration of HUVECs was measured by Transwell migration assay. Results CCR2 was dose-dependently induced by MCP1 in HUVECs. The migrating of cells was significantly inhibited by RS504393. Conclusion CCR2 can accelerate the migration of HUVECs, which may be associated with MCP-1 binding.
Keywords：monocyte chemoattractant protein-1C-C motif chemokine receptor-2RNA interferencecell migration
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 4-5 )