Effect of Perindopril on Vascular Endothelial Function and Endothelial Progenitor Cells of Patients with Coronary Artery Disease
LIU Wei
Abstract：Objective To observe the effect of perindopril on the endothelial progenitor cells ( EPCs) and vascular endothelial function of patients with coronary artery disease. Methods 90 patients with coronary artery disease were randomly divided into control group and research group, with 45 cases in each group. The control group was given conventional therapy, while the other group re-ceived perindopril apart from the regular treatment. After 12 weeks’ treatment, the change of the flow-mediated-dilation ( FMD) func-tion of the brachial artery and EPCs from the peripheral blood of the two groups was compared. Results Compared with the indexes before treatment, the FMD and EPCs of the two groups after treatment increased obviously, with statistically significant difference ( P<0. 05). Compared with the control group, the FMD and EPCs of the research group after treatment increased significantly, and the difference was statistically significant (P<0. 05). Conclusion Perindopril can help mobilize EPCs and improve the endothelial func-tion in the treatment for patients with coronary artery disease, which makes it worthy of application.
Keywords：coronary artery diseaseperindoprilendothelial functionendothelial progenitor cells
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 34-36 )