The Clinical Effect of Mirtazapine Combined with Different Doses of Amisulpride on Depression
WEN Quanqiu
ZHENG Zhaodun
HUANG Shuyi
CHENG Rongxi
Abstract：Objective To evaluate the clinical effect of mirtazapine combined with different doses of amisulpride on depression. Methods 120 patients with depression were randomly divided into observation group (n=60) and control group (n=60). The con-trol group was given amisulpride (50 mg/d) + mirt azapine (15 mg/d). The observation group was given amisulpride (100 mg/d)+ mirtazapine (15 mg/d). The HAMD-17 score and clinical effect were compared between the two groups. Results After treat-ment, the HAMD-17 score of the research group significantly decreased, compared with the control group, with statistically significant difference (P<0. 05). The clinical effect of the research group was significantly better than that of the control group, with statistical significance (P<0. 05). The untoward effect rate of research group and control group was 30. 0% (15/50) and 12. 0% (6/50) re-spectively, with statistically significant difference ( P<0. 05 ) . Conclusion The therapy of 100 mg/d amisulpride combined with 15 mg/d mirtazapine proves superior to 50 mg/d amisulpride combined with 15 mg/d mirtazapine, but along with significantly increased incidence of adverse reactions.
Keywords：depressionmirtazapineamisulpride
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 55-57 )