Effect of High and Low Flux Hemodialysis on Calcium and Phosphate Metabolism and Parathyroid Hormone in Maintained Hemodialysis Patients

JIANG Fu

Abstract：Objective To explore the effect of high and low flux dialysis on calcium and phosphate metabolism and parathyroid hormone in maintained hemodialysis patients. Methods 118 patients with maintenance hemodialysis who received hemodialysis in our hospital were randomly divided into group A and group B with 59 cases in each group. Patients in group A received conventional low flux hemodialysis, and patients in group B received high flux hemodialysis. The level change of serum creatinine, urea nitrogen, para-thyroid hormone, blood calcium and phosphorus of both groups before and one month after hemodialysis were compared. Results The differences in the levels of serum creatinine and urea nitrogen of the two groups before and after hemodialysis were not statistically sig-nificant (all P>0. 05). The parathyroid hormone level of group B was (159. 74±114. 83) μg/L, and its difference was (319. 36± 20. 08) μg/L , which was significantly lower than that of group A (P<0. 05). The serum calcium level of group B after hemodialysis was (2. 32±0. 20) mmol/L, and the difference of serum phosphorus level was (0. 26±0. 07) mmol/L, which was significantly higher than that of group A. The serum phosphorus level of group B after hemodialysis was (2. 19±0. 59) mmol/L, and the difference of ser-um calcium level was (-0. 13±0. 03) mmol/L, which was significantly lower than that of group A (all P<0. 05). Conclusion High flux hemodialysis can effectively correct the disorder of calcium and phosphorus metabolism in maintenance hemodialysis patients by re-ducing the level of serum phosphorus, and reduce the level of parathyroid hormone. It helps to promote the quality of life of the patients and improve the prognosis.