The Clinical Observation of Neoadjuvant Chemotherapy and Postoperative Adjuvant Chemotherapy in the Treatment of Locally Advanced Breast Cancer
GAO Yong
ZHANG Chunmei
LI Zhiguo
ZHANG Didi
Abstract：Objective To explore the clinical effects of neoadjuvant chemotherapy and postoperative adjuvant chemotherapy in the treatment of locally advanced breast cancer. Methods 56 patients with locally advanced breast cancer were randomly divided into two groups. The neoadjuvant chemotherapy group was treated with CAF, with 2 cycles of chemotherapy before the surgery and 4 cycles of chemotherapy after the surgery. The control group adopted CAF regimen for 6 cycles of chemotherapy. The surgical resection rate, 3-year survival, 5-year local recurrence, 5-year distant metastasis rate, 5-year survival rate, CEA, CA-153 level before and after the treatment were compared between the two groups. Results The surgical resection rate, 3-year survival rate, 5-year survival rate, 5-year disease-free survival rate of new adjuvant chemotherapy group were significantly higher than those of the control group. 5-year local recurrence rate and 5-year distant metastasis rate were significantly lower than those of the control group. They were significantly different (P<0. 05). The levels of CEA and CA-153, two tumor markers in new adjuvant chemotherapy group were significantly higher than those in the control group. There were significant differences (P<0. 05). Conclusion The clinical effect of neoadjuvant chemo-therapy is better than that of postoperative adjuvant chemotherapy and it is worth popularizing.
Keywords：locally advanced breast cancerneoadjuvant chemotherapyCAF program
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 47-48,66 )