Detection Significance of Serum Brain Natriuretic Peptide and Myoglobin on Patients with Chronic Heart Failure

FENG Jian; YOU Huayan; ZHENG Jie; LI Jian

Abstract：Objective To explore the detection and clinical significance of serum brain natriuretic peptide ( BNP) and myoglobin ( MYO) on patients with chronic heart failure. Methods 122 patients with chronic heart failure in our hospital from August 2013 to January 2015 were chosen as observation group; 34 healthy volunteers during the same period were chosen as control group. Serum BNP and MYO of all participants were detected. BNP was detected by chemiluminescence method, and MYO was detected by enzyme-linked immunosorbent assay. Results Levels of serum BNP and MYO in the observation group were ( 698. 4 ± 207. 9 ) pg/mL and (133. 6±42. 1) ng/mL respectively, significantly higher than that of the control group. The difference was statistically significant (P<0. 05) . With the increase of cardiac function classification, serum BNP and MYO significantly increased. The difference was statisti-cally significant (P<0. 05). Levels of serum BNP and MYO on patients with Ⅳ grade cardiac function were significantly higher than that of patients with Ⅱand Ⅲ grade cardiac function, while those on patients with Ⅲ grade cardiac function were significantly higher than that of patients withⅡgrade cardiac function. The differences were statistically significant (P<0. 05). Conclusion Serum BNP and MYO in patients with chronic heart failure significantly increase and are closely related to the severity of heart function. They may become important indexes for early diagnosis, disease evaluation and prognosis on patients with chronic heart failure, which is of great clinical significance.