Mechanism of Lipid-Lowering Effect of Paniculata Total Alkaloids

FENG Liang

Abstract：Objective To investigate the mechanism of lipid-lowering effect of paniculata total alkaloids. Methods Animal models of hyperlipidemia rats were constructed by using the high-fat diet. Different concentrations of paniculata total alkaloids were ad-ministered in the form of gavage. Lipid-lowering effect of paniculata total alkaloids was studied by detecting rat apolipoprotein, associ-ated enzymes and active substances. Results The paniculata total alkaloids increased apolipoprotein AI ( ApoAI) , ApoAI / ratio of apolipoprotein B (ApoB). There was statistically significant difference compared with that of the model group (P<0. 05), it also in-creased superoxide dismutase ( SOD) activity and decreased malondialdehyde ( MDA) content. They were significantly different com-pared with those of the model group (P<0. 05), it improved lecithin cholesterol acyltransferase (LCAT) activity, increased Nitric ox-ide (NO) levels and reduced C-reactive protein (CRP). There was statistically significant difference between groups (P<0. 05). Conclusion Paniculata total alkaloids can increase ApoAI by raising high-density lipoprotein cholesterol. It can also activate LCTA, promote reverse cholesterol transport, increase SOD activity, enhance the body′s ability to Hong lipid peroxidation and NO, improve endothelial function and regulate blood lipids from multi-faceted role.